Oushod Sheba

Oushod Sheba

All category

COMBIPEN

ACME LABORATORIES LTD.


INJECTION
(3 LAC UNIT+1 LAC UNIT)/VIAL
4 LAC UNIT VIAL

17.19

Generic Information

Generic name

PROCAINE PENICILLIN + BENZYL PENICILLIN

Indications

It is indicated for the treatment or prevention of any infection caused by Penicillin sensitive bacteria where a long acting Penicillin is required. It is indicated in- Gonorrhoea caused by Penicillin sensitive microorganisns Prevention of endocarditis during dental procedures Gas-gangrene following amputation

Therapeutic Class

Benzylpenicillin & Phenoxymethyl penicillin

Pharmacology

Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-8negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other lactamases. Interferes with cell wall mucopeptide synthesis during active multiplication, resulting in bactericidal activity against susceptible microorganisms.

Dosage & Administration

Add 3 ml of water for injection and shake vigorously. Adults: 4,00,000 units once daily or twice daily. Children: Over 25 kg as for adults; under 25 kg reduce proportionally. In severe cases dose may be doubled. Intramuscular injection is the only route of administration of Procaine Penicillin. Administration This should be injected IM into the buttocks, thigh, deltoid or triceps muscle. In case continuous injection is necessitated, the injection site should be changed every time.

Interaction

Potentially hazardous interactions: invitro Penicillin inactivates Amino- glycosides, so that they should not be mixed in infusion fluids.

Contradictions

Hypersensitivity to penicillin.

Side Effects

Allergic reactions may occur but usually resolve on cessation of therapy.

Pregnancy & Lactation

Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester.

Overdose Effects

Precaution & Warnings

Hypersensitivity to cephalosporins. Renal impairment. CHF. Infant. Elderly.

Storage Conditions

Store at room temperature.