AVOST PLUS

TRAVOPROST + TIMOLOL MALEATE

This Sterile Ophthalmic Solution is indicated for the treatment of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are insufficiently responsive to single therapy with prostaglandin analogue or topical beta blocker.

Drugs for miotics and glaucoma

Travoprost, an isopropyl ester prodrug, is a synthetic prostaglandin F2 alpha analogue that is rapidly hydrolyzed by esterases in the cornea to its biologically active free acid. The travoporst free acid is potent and highly selective for the FP prostanoid receptor. Travoprost free acid is a selective FP prostanoid receptor agonist and is believed to reduce intraocular pressure by increasing the drainage of aqueous humor, which is done primarily through increased uveoscleral outflow and to a lesser extent, trabecular outflow facility.

Instill one drop in the conjunctival sac of the affected eye(s) once daily at about the same time each day, preferably in the evening.

Contraindicated in patients who are hypersensitive to Travoprost, Timolol or any of the components of this preparation.

No serious adverse reactions are reported. Most frequently reported side effects are ocular hyperemia.

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. It should not be used during pregnancy. Use in lactation: Caution should be exercised when Travoprost + Timolol Maleate is administered to a nursing mother.

For ophthalmic use only. Patients should remove their contact lenses prior to instilling this preparation and should not insert their lenses until 15 minutes after instillation of the preparation.

Store in a cool, dry place, away from heat and direct light. Keep out of the reach of children. Do not use more than 4 weeks after opening the bottle