ARTIGO

CINNARIZINE + DIMENHYDRINATE

Cerebral circulatory disorders: Prophylaxis and maintenance therapy for symptoms of cerebral vascular spasms and arteriosclerosis, Sequelae of cerebral and cranial trauma, Postapoplectic disorders, Migraine. Peripheral circulatory disorders: Prophylaxis and maintenance therapy for symptoms of vascular spasms and arteriosclerosis (obliterating arteritis, thromboangitis obliterans, Raynaud's disease, diabetes, acrocyanosis pernio, etc.) such as intermittent claudication,trophic disturbances, pregangrene, trophic and varicose ulcers, paraesthesia, nocturnal cramps,cold extremities. Disorders of balance: Prophylaxis and maintenance therapy for symptoms of labyrinthine arteriosclerosis; vestibular irritability;Meniere's syndrome such as vertigo, dizziness, giddiness, syncopal attacks, tinnitus, nystagmus, nausea and vomiting. Prophylaxis of motion sickness

Anti vertigo drugs

Cinnarizine provides faster relief of various symptoms of cerebral and peripheral circulation disorders and prevents attacks of vascular headache such as migraine. Cinnarizine normalizes cerebral circulation time and curves and improves cerebral irrigation in patients suffering from cerebral circulation disorders. Cinnarizine normalizes arterial pulsations in patients suffering from vasospastic disorders (Raynaud's disease). Cinnarizine significantly increases the rate of inflow of pulsations and the blood flow in the most affected limbs as well as the walking distance of patients suffering from intermittent claudication. Cinnarizine reduces the healing time of crural ulcers. Cinnarizine reduces or eliminates symptoms of vestibular disturbances like, vertigo, tinnitus and autonomic manifestations (nausea, vomiting, pallor and cold extremities) and reduces or prevents future episodes. Dimenhydrinate acts as antihistamine with anti-cholinergic properties.The substance exhibits the anti-emetic & anti-vertigo effects through influencing the chemoreceptor trigger zone.

Usual adult dose: 1 tablet three times daily to be taken with liquid after meal or as advised by the physician.

The anticholinergic and sedative effects of Cinnarizine & Dimenhydrinate may be potentiated by monoamine oxidase inhibitors. In common with other antihistamines, Cinnarizine & Dimenhydrinate may potentiate the sedative effects of CNS depressants including alcohol, barbiturates, narcotic analgesics and tranquillisers. Cinnarizine & Dimenhydrinate may also enhance the effects of antihypertensives, ephedrine and anticholinergics such as atropine and tricyclic antidepressants.

Contraindications are not known. Side-effects such as somnolence and gastrointestinal disturbances are extremely rare. They are transient and may be readily prevented by achieving the optimal dosage gradually. Combination therapy with other drugs is possible whenever indicated.

The most frequently occurring side-effects are somnolence and dry mouth. These reactions are usually mild and disappear within a few days even if treatment is continued. In addition the following adverse reactions are associated with dimenhydrinate and cinnarizine: Dimenhydrinate: paradoxical excitability (especially in children), worsening of an existing angleclosure glaucoma and reversible agranulocytosis. Cinnarizine: constipation, weight gain, tightness of the chest, cholestatic jaundice, extrapyramidal symptoms, lupus-like skin reactions, lichen planus.

Pregnancy: The safety of the combination of Cinnarizine & Dimenhydrinate in human pregnancy has not been established. Lactation: The combination of Cinnarizine & Dimenhydrinate is excreted in human breast milk and should not be taken by women who are breast feeding.

Symptoms: Drowsiness, dizziness and ataxia with anticholinergic effects such as dry mouth, flushing of the face, dilated pupils, tachycardia, pyrexia, headache and urinary retention. Management: General supportive measures should be used to treat respiratory insufficiency or circulatory failure. Gastric lavage with isotonic sodium chloride solution is recommended.

Store below 308 C, away from light & moisture