IBN SINA PHARMACEUTICALS LTD.
ST. JOHN8S WORT
St. John8s Wort is used to treat mild to moderate depression, anxiety and insomnia.
Herbal and Nutraceuticals
A sulfated polysaccharide called calcium spirulan isolated from Spirulina platensis (Arthrospira platensis) was found to inhibit a number of membraned viruses. The viruses inhibited by the polysaccharide included herpes simplex virus 1 (HSV-1), cytomegalovirus, measles virus, mumps virus and HIV-1. Calcium spirulan appears to inhibit the penetration of these viruses into host cells. These studies were performed in vitro. Spirulina has been shown to have hypocholesterolemic activity in experimental animals. The mechanism of this activity is unknown. The spirulina pigment phycocyanin has demonstrated antioxidant activity. It scavenges peroxyl radicals. Phycocyanin has been found to protect against hepatotoxins in rats. The mechanism may be via its antioxidant activity. An extract of Spirulina also protected against carbon tetrachloride hepatotoxicity in rats. The phycocyanin contained in the extract, as well as other antioxidants, probably account for the hepatoprotective effect. Mast-cell mediated immediate-type allergic reactions were found to be inhibited in rats by spirulina. It is speculated that there are substances in spirulina that may inhibit mast-cell degranulation, possibly by affecting the mast-cell membrane. Spirulina platensis extracts have been demonstrated to enhance macrophage function in cats and to enhance humoral and cell mediated immune functions in chickens. The mechanism of these effects is unknown.
The recommended dose of St. John8s Wort capsule in adult is 300 mg three times daily
Symptoms of St. John8s Wort overdose may include dry mouth, dizziness and diarrhea.
St. John8s Wort is generally safe for most people. It sometimes may cause dry mouth, dizziness, constipation and diarrhea.
St. John8s Wort is not recommended for use during pregnancy.Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.
St. John8s Wort should be used cautiously with drugs metabolized by Cytochrome P450 and drugs that lower the seizure threshold.
Keep out of reach of the children. Keep away from direct sunlight; store in a cool and dry place.